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This week's AI-guided docking run narrowed 12,000 candidate scaffolds down to four with predicted sub-nanomolar affinity for the BRAF-Δ pocket. Wet-lab confirmation begins next month.
We are 42% of the way to closing the Phase-1 wet-lab validation round. Thank you to our early backers — full donor list will be published at close.
Six students across three time zones joined the BRAF-Δ program this quarter. Each is paired with a mentor and a scoped 12-week research question.
Registration open for the four-week winter intensive on structural biology and small-molecule design. 50 spots.
Full 100ns MD simulation on the alternate hydrophobic pocket confirms the binding hypothesis. Preprint in preparation.
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